The main hosts of The Loudini Rock and Roll Circus are:

Lou Lombardi (aka "Loudini") – The creator, namesake, and primary host of the show. He is a guitar-driven rock and metal musician who started the podcast to promote emerging artists and celebrate classic rock.

Kevin O'Connor (frequently referred to on the show as "Pittsburgh Kevin") – The long-standing co-host who regularly provides segments, reviews, and music industry insights alongside Lou.

Depending on the specific episode or spin-off segment, the show has also featured co-hosts and contributors like Lily V. Sixx and Keith "The Hawk" Hawkins.